Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2007-10-27
2010-12-14
Mondesi, Robert B (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C435S252300, C435S069100, C435S320100, C536S023200
Reexamination Certificate
active
07851191
ABSTRACT:
Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, α-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms.
REFERENCES:
patent: 4626505 (1986-12-01), Falco
patent: 5130242 (1992-07-01), Barclay
patent: 5605011 (1997-02-01), Bedbrook et al.
patent: 5661017 (1997-08-01), Dunahay et al.
patent: 5804408 (1998-09-01), Hagiwara et al.
patent: 5853973 (1998-12-01), Kakefuda et al.
patent: 6027900 (2000-02-01), Allnut et al.
patent: 7001772 (2006-02-01), Roessler et al.
patent: 0257993 (1998-02-01), None
patent: WO 00/58485 (2000-10-01), None
patent: WO 00/73455 (2000-12-01), None
Hill et al. Mutagenesis ofEscherichia coliacetohydroxyacid synthase isoenzyme II and characterization of three herbicide-insensitive forms. Biochem J. Nov. 1, 1998;335 ( Pt 3):653-61.
Whisstock et al. Quaterly Reviews of Biophysics, 2003, “Prediction of protein function from protein sequence and structure”, 36(3): 307-340.
Witkowski et al. Conversion of a beta-ketoacyl synthase to a malonyl decarboxylase by replacement of the active-site cysteine with glutamine, Biochemistry. Sep. 7, 1999;38(36):11643-50.
Sanford et al., Optimizing the Biolistic Process for Different Biological Applications, Methods in Enzymology, vol. 217, 483-509, 1983.
Bingham et al., FEMS Microbiol. Lett., vol. 65, 77-82, 1989.
Mazur et al., Annu Rev. Plan Physiol. Plant mo. Biol., vol. 40, 441-470, 1989.
Perez et al., Plant Molecular Biology, vol. 13, 365-373, 1989.
Drocourt et al., Nucl. Acids Res., vol. 18 (13), 4009, 1990.
Gatignol et al., Gene, vol. 91, 35-41, 1990.
Accession X06104, NCBI Entrez, 1991.
Guerrero et al. Appl. Microbiol. Biotechnol., vol. 36., 759-762, 1992.
Sutton et al., Transgenic Res., vol. 1, 228-236, 1992.
Accession M13616, NCBI Entrez, 1994.
Dunahay et al., J Phycol., vol. 31, 1004-1012, 1995.
Messina et al., Gene, vol. 165, 213-217, 1995.
Apt et al., Mol. Gen. Genet., vol. 252, 572-579, 1996.
Cermakian et al., Nucl., Acids Res., vol. 24(4), 648-654, 1996.
Rohe et al., Curr. Gene, vol. 29, 587-590, 1996.
Sizova et al., Gene, vol. 181, 13-18, 1996.
Accession 2148078, NCBI Entrez, 1997.
Spychalla et al., Proc. Natl. Acad. Sci USA, vol. 94, 1142-1147, 1997.
Stevens et al., J. Phycol., vol. 33, 713-722, 1997.
Chipman et al., Biochim. Biophysica Acta, vol. 1385, 401-419, 1998.
Lumbreras et al., The Plant Journal, vol. 14, 4, 441-447, 1998.
Funke et al., Mol. Gen. Genet., vol. 262, 12-21, 1999.
Falco et al.: Nucleic Acids Research vol. 13, No. 11, 1985, pp. 4011-4027.
Kaestner et al.: Gene vol. 148, 1994, 67-70.
Bekkaoui et al.: Curr. Genet. vol. 24, 1993, pp. 544-547.
Chang, A.K., and Duggleby, R.G., “Herbicide-resistant forms ofArabidopsis thalianaacetohydroxyacid synthase: characterization of the catalytic properties and sensitivity to inhibitors of four defined mutants,”Biochem J.333:765-777, Biochemical Society (1998).
Chong, C.-K., and Choi, J.-D., “Amino Acid Residues Conferring Herbicide Tolerance in Tobacco Acetolactate Synthase,”Biochem. Biophys. Res. Commun.279:462-467, Academic Press (Dec. 2000).
Ibdah, M., et al., “Homology Modeling of the Structure of Bacterial Acetohydroxy Acid Synthase and Examination of the Active Site by Site-Directed Mutagenesis,”Biochemistry35:16282-16291, American Chemical Society (1996).
Supplementary European Search Report for Application No. EP 02 71 9515, Munich, Germany, completed on Nov. 12, 2004.
International Serch Report for International application No. PCT/US02/12040, United States Patent and Trademark Office, Alexandrisa, Virginia, mailed on Nov. 25, 2003.
Matthews T. Dave
Metz James G.
Ramseier Tom M.
Roessler Paul S.
Chowdhury Iqbal H
Martek Biosciences Corporation
Mondesi Robert B
Sterne Kessler Goldstein & Fox P.L.L.C.
LandOfFree
Product and process for transformation of thraustochytriales... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Product and process for transformation of thraustochytriales..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Product and process for transformation of thraustochytriales... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4221044