Producing sequential polyamino acid resin

Details Producing sequential polyamino acid resin Producing sequential polyamino acid resin

1984-08-30

1986-06-10

Anderson, Harold D.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From carboxylic acid or derivative thereof

528313, 528315, 528321, 528322, C08G 6910

Patent

active

045944091

ABSTRACT:
A sequential polyamino acid resin having a remarkably high molecular weight and special amino acid sequence as repeating unit in the resin can be produced by conducting polycondensation of a peptide active ester acid salt in an aprotic polar solvent in the presence of a tertiary amine and phosphorus pentoxide.

REFERENCES:
patent: 4132746 (1979-01-01), Urry et al.
patent: 4525576 (1985-06-01), Hayashi et al.
Bull. Chem. Soc. Japan 31 (7), 802-807: Kitaoka et al., "Synthesis of Poly-(L-Prolyl-L-Leucyl-Glycyl . . . " (Oct. 1958).
J. Pharm. Sci. 63, 313-327: Johnson, "Synthesis, Structure, and Biological Properties of Sequential Polypeptides" (Mar. 1974).
Chemistry and Biochemistry of Amino Acids, Peptides, and Proteins, vol. 4, pp. 29-63: Jones, "Sequential Polypeptide Synthesis".

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