Producing nucleosides

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

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435253, 435313, 435813, 435818, 435832, 435839, C12P 1940

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045783365

ABSTRACT:
In a fermentation procedure for the production of nucleosides i.e. inosine and/or guanosine using an adenine-requiring microorganism, the fermentation is carried out by allowing a source of adenine to be present in the medium in an excess amount over the amount of adenine that would be conductive to a maximum yield of inosine and/or guanosine in aerobic culture using ordinary air, and cultivating the microorganism while an oxygen-rich gas is bubbled into the medium. Thus, inosine and/or guanosine are accumulated in high yield in the fermentation broth.

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Isamu Shiio and Kenji Ishii, Journal of Biochemistry (Japan), vol. 69, pp. 339-347 (1971).
Hiroshi Matsui et al.; Agricultural and Biological Chemistry, 43, 393.about.394 (1979).
Masataka Tate, Hiroshiro Shibai and Kaetsu Kobayashi; Ann. Meet. Agricultural an Chemical Society of Japan (1976) Abstract P.355.

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