Producing immunogenic constructs using soluable carbohydrates ac

Details Producing immunogenic constructs using soluable carbohydrates ac Producing immunogenic constructs using soluable carbohydrates ac

1995-06-07

1998-12-15

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

4241781, 4241931, 42419611, 42419711, 5303911, 530403, 530411, A61K 39385, C07K 1700

Patent

active

058493018

ABSTRACT:
The invention relates to a process for producing an immunogenic construct comprising activating at least one first carbohydrate-containing moiety with CDAP, CTEA or pNPC, and covalently joining the activated first moiety to a second moiety. Preferably, the first moiety is a polysaccharide and the second moiety is a protein. Immunogenic constructs are prepared by this process using either direct or indirect conjugation of the first and second moieties.

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