Producing highly specific, low cross-reactive antibody by immuni

Details Producing highly specific, low cross-reactive antibody by immuni Producing highly specific, low cross-reactive antibody by immuni

1983-06-20

1988-02-02

Marantz, Sidney

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 68, 43524027, 436547, 436548, 436804, 436815, 436817, 436818, 436823, 530387, 935 89, 935 93, 935 95, 935102, 935110, G01N 3353, G01N 33531, G01N 33534

Patent

active

047228997

ABSTRACT:
A process for producing an antibody having a high specificity to a first antigen and a low cross-reactivity with at least one second antigen, said first antigen comprising a desired antigenic determinant and said second antigen comprising at least one antigenic determinant which is structurally related to said desired antigenic determinant of said first antigen, which process comprises treating a mammal with a copolymer of D-glutamic acid and D-lysine coupled with said second antigen whereby to induce a substantially effective immunological tolerance to said second antigen and then immunizing said mammal with said first antigen. This process results in a higher productivity of a mammal cell capable of producing said desired antibody by culturing said mammal cell, for example, by forming a hybridoma with a suitable tumor cell and implanting the hybridoma into another mammal. The antibody or antiserum of this invention may with advantage be used for immunoassay such as radioimmunoassay.

REFERENCES:
patent: 4156081 (1979-05-01), Singh
patent: 4172124 (1979-10-01), Koprowski
patent: 4524025 (1985-06-01), Geltosky
Kohler, G. et al., Nature 256, 495-497 (1975).
Tateishi, K. et al., Steroids, 36(3), 283-288 (Sep. 1980).

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