Producing a protein in a mammal by injection of a DNA-sequence i

Details Producing a protein in a mammal by injection of a DNA-sequence i Producing a protein in a mammal by injection of a DNA-sequence i

1994-06-21

1997-08-12

Chambers, Jasemine C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

935 53, 935 56, 935 63, A61K 4800, C12N 1500

Patent

active

056566107

ABSTRACT:
The striated muscle of the tongue of an animal (in particular, a mammal) is employed as the target tissue for direct DNA injection of an exogenous polynucleotide sequence encoding a biologically active molecule. The DNA is incorporated into the tongue muscle cells and the polypeptide encoded thereby expressed, resulting in the production of a biologically active molecule. Superior levels of expression of the injected exogenous polynucleotide are achieved relative to injection in other types of cells, in particular other types of muscle cells. Moreover, the striated muscle of the tongue represent an easily accessed anatomic location that has not previously been used for direct DNA injection.

REFERENCES:
Acsadi et al (1991) Nature 352, 815-818.
Prigozy et al (1993) Somat. Cell Molec. Gen. 19, 111-122.

Affiliated with

Also associated with

Rating

Producing a protein in a mammal by injection of a DNA-sequence i does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Producing a protein in a mammal by injection of a DNA-sequence i, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Producing a protein in a mammal by injection of a DNA-sequence i will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-160617