Prodrugs of thrombin inhibitors

Details Prodrugs of thrombin inhibitors Prodrugs of thrombin inhibitors

2006-12-05

2006-12-05

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S422000, C514S444000, C514S461000, C548S202000, C548S517000, C548S527000, C548S950000

Reexamination Certificate

active

07144902

ABSTRACT:
The present invention relates to prodrugs of pharmacologically active five-membered heterocyclic amidines from which are produced in vivo compounds which are competitive inhibitors of trypsin-like serine proteases, in particular thrombin and kininogenases such as kallikrein, to the preparation thereof and to the use thereof as medicines. The invention also relates to pharmaceutical compositions which comprise the prodrugs of the active compounds as ingredients, and to the use of the compounds as thrombin inhibitors, anticoagulants and as antiinflammatory agents.

REFERENCES:
patent: 6114358 (2000-09-01), Baucke et al.
patent: 6492402 (2002-12-01), Lee et al.
patent: 6683055 (2004-01-01), Hillen et al.
patent: 6740647 (2004-05-01), Baucke et al.
patent: 196 32 773 (1998-02-01), None
patent: 0 672 658 (1995-09-01), None
patent: WO 95/23609 (1995-09-01), None
patent: WO 97/31939 (1997-02-01), None
patent: WO 97/23499 (1997-07-01), None
patent: WO 99/37611 (1999-07-01), None
patent: WO 99/37668 (1999-07-01), None

Affiliated with

Also associated with

Rating

Prodrugs of thrombin inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Prodrugs of thrombin inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prodrugs of thrombin inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3683008