Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-12-09
1997-09-02
Wilson, James O.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514261, 514265, 514931, 514934, 544276, 544277, 544267, A61K 3152
Patent
active
056631758
ABSTRACT:
Certain prodrugs such as ##STR1## are useful in the inhibition of herpes virus thymidine kinase, the prevention or treatment of recurrent infection by herpes virus, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing or treating recurrent infection by herpes virus are also described.
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Klein et al., Antiviral Research, vol. 14, pp. 207-214, (1990).
Ashton, et al., "A Potent, Selective, Non-Substrate Inhibitor of HSV-1 Thymidine Kinase:", Nucleosides & Nucleotides, 8(5&6), pp. 1157-1158 (1989).
Bourne, et al., "Assessment of a Selective Inhibitor of Herpes Simples Virus Thymidine Kinase . . . ", Antimicrobial Agents and Chemo., vol. 36, No. 9, pp. 2020-2024, Sep. 1992.
Leib, et al., "Specific Inhibitors of Herpes Simplex Virus Thymidine Kinase Diminish Reactivation . . . ", Antimocrobial Agents and Chemo., vol. 34, No. 6, pp. 1285-1286, Jun. 1990.
Nsiah, et al., "Suppression of Herpes Simplex Virus Type 1 Reactivation from Latency . . . ", Antimicrobial Agents and Chemo., vol;. 34, No. 8, pp. 1551-1555, Aug. 1990.
Klein, et al., "Effect of a Thymidine Kinase Inhibitor (L-653,180) on Antiviral Treatment . . . ", Antiviral Research 14, pp. 207-214 (1990).
Jacobson, et al., "Herpes Simplex Virus Thymidine Kinase and Specific Stages of Latency in Murine Trigeminal Ganglia", J. of Vir., pp. 6903-6908, vol. 67, No. 11, Nov. 1993.
Spadari, et al., "L-Thymidine is Phosphorylated by Herpes Simplex Virus Type 1 Thymidine Kinase and Inhibits Viral Growth", J. of Med. Chem., pp. 4214-4220, 35, (1992).
Karkas John D.
Langen Derek Von
Maccoss Malcolm
Tolman Richard L.
Ayler Sylvia A.
Daniel Mark R.
Merck & Co. , Inc.
Wilson James O.
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