Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2007-08-14
2007-08-14
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C564S193000
Reexamination Certificate
active
10250448
ABSTRACT:
This invention relates to synthetic excitatory amino acid prodrugs according to formula (I) and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psychiatric disorders
REFERENCES:
patent: 5661184 (1997-08-01), Helton et al.
patent: 5726320 (1998-03-01), Robey
patent: 5750566 (1998-05-01), Monn et al.
patent: 5882671 (1999-03-01), Helton et al.
patent: 5925680 (1999-07-01), Helton et al.
patent: 5925782 (1999-07-01), Monn
patent: 0 696 577 (1996-02-01), None
patent: 1 052 246 (2000-11-01), None
patent: PCT/US02/36145 (2002-05-01), None
patent: WO 00 04010 (2000-01-01), None
patent: WO 02 22627 (2002-03-01), None
patent: WO 02/055485 (2002-07-01), None
patent: WO 03/006489 (2003-01-01), None
patent: WO 03/045898 (2003-06-01), None
C. Y. Yang et al., Intestinal peptide transport systems and oral drug availability,Pharm. Res.1999, 16(9), 1331-1343.
V. Ganapathy et al., Intestinal transport of amino acids and peptides,Physiology of the gastrointestinal tract, L. R. Johnson, Editor. 1994, Raven Press: New York, pp. 1773-1794.
D. M. Mathews et al., Peptide absorption,Gastroenterology1976, 71, 151-161.
K. Inui, M. et al., Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: Specific transport systems in apical and basolateral membranes,J. Pharmacol. Exp. Ther, 1992, 261(1), 195-201.
Kim, J. S. et al., Absorption of ACE inhibitors from small intestine and colon,J. Pharm. Sci.1994, 83(9), 1350-1356.
Hashimoto, N. et al., Renin inhibitor: transport mechanism in rat small intestinal brush-border membrane vesicles,Pharm. Res.1994, 11(10), 1448-1451.
Döring, F. et al., Minimal molecular determinants of substrates for recognition by the intestinal peptide transporter,J. Biol. Chem.1998, 273, 23211-23218.
Han, H. K. et al., 5′-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter,Pharm. Res.1998, 15, 1154-1159.
Hu, M. et al, Use of peptide carrier system to improve the intestinal absorption of L-alpha-methyldopa: carrier kinetics, intestinal permeabilities and in vitro hydrolysis of dipeptidyl derivatives of L-alpha-methyldopa.Pharm. Res.1989, 6, 66-70.
Bailey, P. D. et al., How to make drugs orally active: a substrate template for peptide transporter PepT1,Angew. Chem. Int. Ed. Eng.2000, 39(3), 506-508.
Bai, Jane P. F. et al, Structural Specificity of Mucosal-Cell Transport and Metabolism of Peptide Drugs: Implication of Oral Peptide Drug Delivery.,Pharm. Res., 9 (8), 1992, 969-978.
Langguth P. et al., The challenge of proteolytic enzymes in intestinal peptide delivery.,Journal of Controlled Release, 46, 1997, 39-57.
Walter E. et al., The intestinal peptide carrier: A potential transport system for small peptide derived drugs,Adv. Drug Deliv. Rev.1996, 20, 33-58.
Amidon G. L. et al., Absorption of Peptide and Peptidomimetic drugs.,Annu. Rev. Pharmacol. Toxicol., 1994, 34, 321-341.
Bai, Jane P-F et al., Utilization of Peptide Carrier System To Improve Intestinal Absorption: Targeting Prolidase as a Prodrug-Converting Enzyme.,J. Pharm. Sci., 1992, 81 (2), 113-116.
Lee, Chao-Pin et al., Advanced Drug Delivery, 23, 1997, 47-62.
Pauletti, Giovanni M. et al., Advanced Drug Delivery Reviews, 1997, 27, 235-256.
Oliyai, Reza, Advanced Drug Delivery Reviews, 1996, 19, 275-286.
Steffansen, Bente et al., European Journal of Pharmaceutical Sciences, 1999, 8, 67-73.
Nielsen, Carsten Uhd et al., Journal of Controlled Release, 2001, 76, 129-138.
Steingrimsdottir, Hlif et al., Antimicrobial Agents and Chemotherapy, 2000, 44 (1), 207-9.
Anand, Banmeet S. et al., Current prodrug strategies via membrane transporters/receptors, Expert Opin. Biol. Ther., 2002, 2(6), 607-620.
Dantzig, Anne H., Oral absorption of β-lactams by intestinal peptide transport proteins, Advanced Drug Delivery Reviews, 1997, 63-76.
Coffey David Scott
Monn James Allen
Pedersen Steven Wayne
Pedregal-Tercero Concepcion
Anderson Arvie J.
Coppins Janet L.
Eli Lilly and Company
Hostettler Danica
Saeed Kamal A.
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