Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Reexamination Certificate
2006-05-02
2006-05-02
Richter, Johann (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C562S502000
Reexamination Certificate
active
07038077
ABSTRACT:
This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psychiatric disorders.
REFERENCES:
patent: 5661184 (1997-08-01), Helton et al.
patent: 5726320 (1998-03-01), Robey
patent: 5750566 (1998-05-01), Schoepp et al.
patent: 5882671 (1999-03-01), Helton et al.
patent: 5912248 (1999-06-01), Fernandez et al.
patent: 5925680 (1999-07-01), Helton et al.
patent: 5925782 (1999-07-01), Monn
patent: 5958960 (1999-09-01), Massey et al.
patent: 0 696 577 (1996-02-01), None
patent: 1 052 246 (2000-11-01), None
patent: WO 00 04010 (2000-01-01), None
patent: WO 02 22627 (2002-03-01), None
patent: WO 02/055485 (2002-07-01), None
patent: WO 03/006489 (2003-01-01), None
PCT/US02/36145, pending, Bueno Melando et al.
C. Y. Yang et al., Intestinal peptide transport systems and oral drug availability,Pharm. Res.1999, 16(9), 1331-1343.
V. Ganapathy et al., Intestinal transport of amino acids and peptides,Physiology of the gastrointestinal tract, L. R. Johnson, Editor. 1994, Raven Press: New York, pp. 1773-1794.
D. M. Mathews et al., Peptide absorption,Gastroenterology1976, 71, 151-161.
K. Inui, M. et al., Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: Specific transport systems in apical and basolateral membranes,J. Pharmacol. Exp. Ther, 1992, 261(1), 195-201.
Kim, J. S. et al., Absorption of ACE inhibitors from small intestine and colon,J. Pharm. Sci.1994, 83(9), 1350-1356.
Hashimoto, N. et al., Renin inhibitor: transport mechanism in rat small intestinal brush-border membrane vesicles,Pharm. Res.1994, 11(10), 1448-1451.
Döring, F. et al., Minimal molecular determinants of substrates for recognition by the intestinal peptide transporter,J. Biol. Chem.1998, 273, 23211-23218.
Han, H. K. et al., 5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter,Pharm. Res.1998, 15, 1154-1159.
Hu, M. et al, Use of peptide carrier system to improve the intestinal absorption of L-alpha-methyldopa: carrier kinetics, intestinal permeabilities and in vitro hydrolysis of dipeptidyl derivatives of L-alpha-methyldopa.Pharm Res.1989, 6, 66-70.
Bailey, P. D. et al., How to make drugs orally active: a substrate template for peptide transporter PepT1,Angew. Chem. Int. Ed. Eng.2000, 39(3), 506-508.
Bai, Jane P. F. et al, Structural Specificity of Mucosal-Cell Transport and Metabolism of Peptide Drugs: Implication for Oral Peptide Drug Delivery.,Pharm. Res., 9(8), 1992, 969-978.
Langguth P. et al., The challenge of proteolytic enzymes in intestinal peptide delivery.,Journal of Controlled Release, 46, 1997, 39-57.
Walter E. et al., The intestinal peptide carrier: A potential transport system for small peptide derived drugs,Adv. Drug. Deliv. Rev.1996, 20, 33-58.
Amidon G. L. et al., Absorption of Peptide and Peptidomimetic drugs.,Annu. Rev. Pharmacol. Toxicol.,1994, 34, 321-341.
Bai, Jane P-F et al., Utiliization of Peptide Carrier System To Improve Intestinal Absorption: Targeting Prolidase as a Prodrug-Converting Enzyme.,J. Pharm. Sci.,1992, 81 (2), 113-116.
Lee, Chao-Pin et al., Advanced Drug Delivery, 23, 1997, 47-62.
Pauletti, Giovanni M. et al., Advanced Drug Delivery Reviews, 1997, 27, 235-256.
Oliyai, Reza, Advanced Drug Delivery Reviews, 1996, 19, 275-286.
Steffansen, Bente et al., European Journal of Pharmaceutical Sciences, 1999, 8, 67-73.
Nielsen, Carsten Uhd et al., Journal of Controlled Release, 2001, 76, 129-138.
Steingrimsdottir, Hlif et al., Antimicrobial Agents and Chemotherapy, 2000, 44 (1), 207-9.
Anand, Banmeet S. et al., Current prodrug strategies via membrane transporters/receptors, Expert Opin. Biol. Ther., 2002, 2(6), 607-620.
Dantzig, Anne H., Oral absorption of β-lactams by intestinal peptide transport proteins, Advanced Drug Delivery Reviews, 1997, 63-76.
Bueno Melendo Ana Belen
Dantzig Anne Hollins
De Dios Alfonso
Dominguez-Fernandez Carmen
Herin Marc Francis
Anderson Arvie J.
Eli Lilly and Company
Nwaonicha Chukwuma
Winter Mark A.
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