Prodrugs of Ara-A an antiviral agent

Details Prodrugs of Ara-A an antiviral agent Prodrugs of Ara-A an antiviral agent

1982-06-21

1985-01-22

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 26, A61K 3170, C07H 1906

Patent

active

044951809

ABSTRACT:
This invention relates to new organic compounds that are prodrugs of the antiviral agent Ara-A which is 9-(.beta.-D-arabinofuranosyl)adenine. These compounds by virtue of their high lipid solubility will penetrate the stratum cornium and on entry the enzymatic cleavage will regenerate the antiviral compound Ara-A.

REFERENCES:
patent: 3551409 (1970-12-01), Kampe et al.
patent: 3787391 (1974-01-01), Jahn et al.
patent: 3901876 (1975-08-01), Vorbruggen et al.
patent: 4388308 (1983-06-01), Hamilton et al.

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