Prodrugs of anticancer agents employing substituted aromatic...

Details Prodrugs of anticancer agents employing substituted aromatic... Prodrugs of anticancer agents employing substituted aromatic...

2005-08-30

2005-08-30

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S332000, C514S567000, C514S616000, C514S637000, C514S568000, C536S028500, C548S100000, C548S556000, C544S239000, C544S298000, C544S001000, C546S338000, C546S313000, C546S290000, C546S300000, C546S301000, C546S262000, C562S405000, C562S426000, C562S465000, C562S443000, C562S450000, C562S457000, C562S458000, C564S156000

Reexamination Certificate

active

06936597

ABSTRACT:
Polymeric prodrugs of the formula:whereinB is selected from the group consisting of OH, leaving groups, residues of amine-containing moieties and a residues of hydroxyl-containing moieties;Y1is selected from the group consisting of O, S, and NR5;M is NR3, O or S;Ar is a moiety which when included in Formula I forms a multi-substituted aromatic or heteroaromatic hydrocarbon or a multi-substituted heterocyclic group;(m) is zero or a positive integer;R1-3and R5are independently selected from the group consisting of hydrogen, C1-6alkyls, C3-12branched alkyls, C3-8cycloalkyls, C1-6substituted alkyls, C3-8substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6heteroalkyls, substituted C1-6heteroalkyls, C1-6alkoxy, phenoxy and C1-6heteroalkoxy; andR4is a polymeric residue;as well as methods of making and using the same are disclosed.

REFERENCES:
patent: 5965119 (1999-10-01), Greenwald et al.
patent: 6180095 (2001-01-01), Greenwald et al.
patent: 6303569 (2001-10-01), Greenwald et al.
patent: WO 99/30561 (1999-06-01), None
patent: WO 01/17501 (2001-03-01), None
Butterworth et al. (Journal of Medicinal Chemistry (1987), 30 (8), 1295-1302) (abstract sent).
Schulz et al. (Journal of Macromolecular Science, Pure and Applied Chemistry (1993), A30 (1), 91-103) (abstract sent).
Burger et al. (Journal of Organic Chemistry (1995), 60 (23), 7382-3) (abstract sent).
Underliner et al., WO 2001017501 A1 (Mar. 15, 2001) (Abstract sent).

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