Prodrugs of 6-mercaptopurine and 6-thioguanine

Details Prodrugs of 6-mercaptopurine and 6-thioguanine Prodrugs of 6-mercaptopurine and 6-thioguanine

1990-06-25

1992-06-09

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544276, 544265, A61K 31495, C07D47324, C07D47338

Patent

active

051207400

ABSTRACT:
Prodrugs for the treatment of kidney tumors are disclosed. The prodrugs are conjugates that can require the cooperation of multiple enzymes in the kidney to release 6-mercaptopurine or 6-thioguanin, or can selectively release 6-thioguanine. Methods for use of these prodrugs are also disclosed.

REFERENCES:
patent: 2875203 (1959-02-01), Shive et al.
patent: 2952539 (1960-09-01), Dersch et al.
patent: 3149111 (1964-09-01), Hitchings et al.
patent: 3232937 (1966-02-01), Hitchings et al.
patent: 3232938 (1966-02-01), Hitchings et al.
patent: 3238207 (1966-03-01), Hitchings et al.
patent: 3567705 (1971-03-01), Cerny et al.
patent: 4139705 (1979-02-01), Dunbar et al.
patent: 4169948 (1979-10-01), Dunbar et al.
patent: 4443435 (1984-04-01), Bodor et al.
patent: 4714701 (1987-12-01), Beauchamp
Y. Hwang et al., 251, J. Pharm. Exp., 448-454 (1989).
L. Lash et al., 276, Arch. Bio. Biophys., 322-330 (1990).
A. Garcia-Raso et al., 51, J. Org. Chem., 4285-4287 (1986).
M. Winitz et al., 78, J. Amer. Chem. Soc., 2423-2430 (1956).
FASEB Journal, Mar. 20, 1988, Abst. 4922, p. A1143, A. Elfarra et al.
FASEB Journal, Mar. 19, 1989, Abst. 1165, p. A427, A. Elfarra et al.
Vol. 30, Proc. A.A.C.R., Mar. 1989, p. 590, Abstract 2347, R. Robins et al.
Vol. 30, Proc. A.A.C.R., Mar. 1989, p. 596, Abstract 2374, J. Fujitaki et al.
Vol. 30, Proc. A.A.C.R., Mar. 1989, p. 597, R. Finch et al. (Abstract 2375, 2377), R. Willis et al. (Abstract 2376), and G. Crabtree et al. (Abstract 2378).
Vol. 30, Proc. A.A.C.R., Mar. 1989, p. 599, Abstract 2384, T. Riley et al.
K. Van Scoik et al., 16, Drug Metab. Rev., 157-174 (1985).
J. Nelson et al., 46, J. Can. Res., 137-140 (1986).
Raz et al., Pharmacokinetics of Sulfur-35-Labeled N-[8-(6-purinylthio)valeryl]glycine Ethyl Ester, Advan. Antimicrob. Antineopl. Chemother. Proc. Int. Congress Chemother., 7th, 1971, 2, 59-61.
Hwang, I. Y.; Elfarra, A. A., Cysteine S-Conjugates . . . , J. Pharmacol. Exp. Ther., 1989, vol. 251(2).

Affiliated with

Also associated with

Rating

Prodrugs of 6-mercaptopurine and 6-thioguanine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Prodrugs of 6-mercaptopurine and 6-thioguanine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prodrugs of 6-mercaptopurine and 6-thioguanine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1804716