Prodrugs of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S339000, C546S270100

Reexamination Certificate

active

11056029

ABSTRACT:
The present invention relates to new compounds of general formulahaving thrombin-inhibiting activity. Exemplary are:1-Methyl-2-[4-(N-hydroxyamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-ethoxycarbonylethyl)-amide, and1-Methyl-2-[4-(N-methoxycarbonylamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide.

REFERENCES:
patent: 6087380 (2000-07-01), Hauel et al.
patent: 6414008 (2002-07-01), Hauel et al.
patent: 6469039 (2002-10-01), Hauel et al.
patent: 6710055 (2004-03-01), Hauel et al.
patent: 6900229 (2005-05-01), Hauel et al.
patent: WO 98/37075 (1998-08-01), None
Hauel, N., et al; “Disbustituted Bicyclic Heterocycles, The Preparation Thereof and their Use as Pharmaceutical Compositions”; U.S. Appl. No. 10/192,041, filed Jul. 10, 2002.

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