Prodrugs for enzyme mediated activation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514461, 4351885, A61K 31335, A61K 3134

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active

056210027

ABSTRACT:
Enzymatically clearable prodrugs with reduced Michaelis-Menten constant (Km) are described.

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K.D. Bagshawe et al., "Antibody Directed Enzyme Prodrug Therapy (Adept): Clinical Report," Disease Markers, 1991, vol. 9, pp. 233-238.
K.M. Munir et al., "Thymidine kinase mutants obtained by random sequence selection," Proc. Natl. Acad. Sci. USA, 1993, vol. 90, pp. 4012-4016.

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