Prodrugs for antibody directed enzyme prodrug therapy

Details Prodrugs for antibody directed enzyme prodrug therapy Prodrugs for antibody directed enzyme prodrug therapy

1994-12-21

1996-12-24

Feisee, Lila

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

5303917, 560134, 560135, 560136, 560137, 564 15, 564162, 564180, A61K 39395, C07K 1600, C07C26100, C07F 902

Patent

active

055871615

ABSTRACT:
Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs substrates for carboxypeptidase G2 (CPG2) and yield more cytotoxic drugs than known products of CPG2 catalysed

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