Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-07-22
2008-07-22
Canella, Karen A (Department: 1643)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S017400, C514S018700, C530S323000, C530S329000, C530S330000, C530S331000, C530S332000, C530S345000, C536S006400
Reexamination Certificate
active
07402556
ABSTRACT:
The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or di-peptide linkage, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by plasmin. Also disclosed are methods of making and using the prodrug compounds.
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DuBois Vincent
Passioukov Alexandre
Trouet Andre
Canella Karen A
Lahive & Cockfield LLP
Medarex Inc.
Remillard, Esq. Jane E.
Soroos Cynthia M.
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