Prodrug esters of phosphonosulfonate squalene synthetase inhibit

Details Prodrug esters of phosphonosulfonate squalene synthetase inhibit Prodrug esters of phosphonosulfonate squalene synthetase inhibit

1995-06-07

1997-04-08

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

C07F 940

Patent

active

056189648

ABSTRACT:
New prodrug esters of salt forms of the phosphonosulfonate squalene synthetase inhibitor having the structure ##STR1## are provided wherein R is alkyl, arylalkyl, aryl or acylthioalkyl. These prodrug esters inhibit cholesterol biosynthesis and therefore are used in lowering serum cholesterol and in treating atherosclerosis.

REFERENCES:
patent: 5332728 (1994-07-01), Biller

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