Prodrug compounds for dermal application

Details Prodrug compounds for dermal application Prodrug compounds for dermal application

1984-02-27

1986-05-13

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

544125, C07J 500

Patent

active

045885257

ABSTRACT:
Prodrug compounds for dermal application of topical medicaments, such as 6-aminonicotinamide for treatment of psoriasis, are linked by an enzyme cleavable group to a carrier side chain, such as succinyl piperidate or morpholidate. The neutral lipophilic compounds are rapidly absorbed into the epithelial cells where they are enzymatically cleaved to release the active drug in an ionic form which is retained within the cells.

REFERENCES:
patent: 4196204 (1980-04-01), Petzold et al.
patent: 4224320 (1980-09-01), Dahl et al.
patent: 4258052 (1981-03-01), Yu et al.
patent: 4329294 (1982-05-01), McCombs

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