Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1986-12-09
1995-09-19
Furman, Keith C.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4352523, 4353201, 514 12, 530383, 536 235, 930100, A61K 3837, C07K 14755, C12N 506, C12N 1512
Patent
active
054515211
ABSTRACT:
This invention relates to recombinant Factor VIII:c variants, methods to produce the variants and pharmaceutical compositions containing same. The variants of this invention are characterized by modification of one or more specific proteolytic cleavage sites encompassing the arginine residues at positions 226, 336, 562, 740, 776, 1313, 1648, or 1721. The variants possess similar procoagulant activity to that of human Factor VIII:c.
REFERENCES:
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Vehar et al Nature vol. 312 Nov. 22, 1984 pp. 337-342 "Structure of human factor VIII".
Wood et al Nature vol. 312 Nov. 22, 1984 pp. 330-336 "Expression of active human factor VIII from recombinant cDNA clones".
Toole et al Nature vol. 312 Nov. 22, 1984 pp. 342-347 "Molecular cloning of a cDNA encoding human antihaehophilius factor".
Norris et al Nucl Acids Res vol. 11 pp. 5103-5112 1983.
Orr et al Thrombos Haemostus vol. 54(1) pp. 54-1985 Abstract 5321.
Eaton et al Feb. 1986 Biochem vol. 25 pp. 505-512 "Proteolytic processing of human factor VIII correlation of specific cleavages by thrombin, factor Xa, . . . ".
Andersson et al Proc Natl Acad Sci vol. 83 May 1984 pp. 2979-2983 "Isolation and characterization of human factor VIII: Molecular forms in".
Burke et al J Biol Chem vol. 261 (27) Sep. 25, 1986 "The functional domains of coagulation factor VIII:C".
Kaufman Randal J.
Pittman Debra D.
Toole, Jr. John J.
Collins Bruce M.
DesRosier Thomas J.
Furman Keith C.
Genetics Institute Inc.
Jacobson D. C.
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