Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-06-14
2005-06-14
McKane, Joseph K. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
06906204
ABSTRACT:
The present invention relates to a processing method for preparing lovastatin and simvastatin which comprises the steps of (1) performing lactonization of mevinic acid and its homologous compounds in the presence of a mixed organic solvent without an acid catalyst through nitrogen sweep; and (2) making crystals. In the process of the present invention, lovastatin and simvastatin highly purified can be produced in a high yield and especially, heterodimers formed as a by-product can be reduced remarkably. Therefore, the processing method of the present invention can be convenient and economical.
REFERENCES:
patent: 5939564 (1999-08-01), Kumar et al.
patent: 6294680 (2001-09-01), Vries et al.
patent: 6380401 (2002-04-01), McManus et al.
Cho Hong-suk
Choi Kwang-do
Kim Jin-wan
Lee Kwang-hyeg
Lee Sang-ho
Anderson Rebecca
CJ Corp.
McKane Joseph K.
Swanson & Bratschun L.L.C.
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