Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...
Reexamination Certificate
2005-12-30
2011-10-04
Menon, Krishnan S (Department: 1777)
Chemistry: molecular biology and microbiology
Maintaining blood or sperm in a physiologically active state...
C435S372000, C435S040510, C436S010000, C436S017000, C436S176000
Reexamination Certificate
active
08029978
ABSTRACT:
The present invention relates to a processing method for long-term stabilization of biological red blood cell volume. The red blood cells can be further used in reference materials and calibrators of a hematology analyzer. The method of the present invention comprises contacting the sample with a solution comprising a membrane-fixation reagent and an aldehyde for a processing period to terminate or slow down the red blood cell metabolism. It is provided by experiments that such process enables the volume of the red blood cells to be stable in a period over 120 days.
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Oxford Press. http://www.oup.com/uk/orc/bin/9780199264636/01student/video/ch18/.
Liu Mulong
Xu Zuyue
Zhang Hui
Bethards Matthew S.
Christensen Kory D.
Fritchman Rebecca M
Menon Krishnan S
Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
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