Processing method for the long-term stabilization of...

Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...

Reexamination Certificate

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Details

C435S372000, C435S040510, C436S010000, C436S017000, C436S176000

Reexamination Certificate

active

08029978

ABSTRACT:
The present invention relates to a processing method for long-term stabilization of biological red blood cell volume. The red blood cells can be further used in reference materials and calibrators of a hematology analyzer. The method of the present invention comprises contacting the sample with a solution comprising a membrane-fixation reagent and an aldehyde for a processing period to terminate or slow down the red blood cell metabolism. It is provided by experiments that such process enables the volume of the red blood cells to be stable in a period over 120 days.

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Oxford Press. http://www.oup.com/uk/orc/bin/9780199264636/01student/video/ch18/.

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