Processes of converting taxanes into baccatin III

Details Processes of converting taxanes into baccatin III Processes of converting taxanes into baccatin III

1992-08-14

1993-04-13

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30514

Patent

active

052024482

ABSTRACT:
The present invention relates to a process of converting partially purified taxane mixtures into Baccatin III. The process for the preparation of Baccatin III includes contacting a mixture containing at least one taxane compound having an ester linkage at the C-13 position with at least one borohydride reducing salt in a reaction solvent in the present of a Lewis acid.

REFERENCES:
Miller et al.; JOC, 46, 1469 (1981).
Magri et al., JOC, 51, 3239 (1986).

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