Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substitut

Details Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substitut Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substitut

1990-02-20

1993-02-23

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544318, 548470, 5483761, 5483415, 552105, 556288, 566 55, 566 57, 566 60, C07F 504, C07D73902, C07C 6966, C07C31718

Patent

active

051891646

ABSTRACT:
A process for synthesizing syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof from the corresponding keto-hydroxy compounds, which process comprises: providing a reaction medium comprising sodium borohydride and an alkoxydialkylborane compound; treating the keto-hydroxy compound with said reaction medium under conditions wherein a cyclic boronate ester is formed; and cleaving the cyclic boronate ester to obtain the dihydroxy product.
The product compounds, or derivatives thereof, are useful as anti-atherosclerotic agents.

REFERENCES:
patent: 4870199 (1989-09-01), Chen et al.
patent: 4983759 (1991-01-01), Inoue et al.

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