Processes for the synthesis of olanzapine

Details Processes for the synthesis of olanzapine Processes for the synthesis of olanzapine

2011-01-04

2011-01-04

Coleman, Brenda L (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

07863442

ABSTRACT:
There is provided a process for the preparation of olanzapine comprising:i) reacting 4-amino-2-methyl-10H-thieno-[2,3-b][1,5]benzodiazepine and N-methylpiperazine in a C1to C4alcoholic solvent or mixture thereof at suitable temperature and for a suitable time,ii) cooling the reaction mixture, andiii) isolating the precipitated olanzapine.

REFERENCES:
patent: 5229382 (1993-07-01), Chakrabarti et al.
patent: 2004/0048854 (2004-03-01), Patel et al.
patent: 2005/0159408 (2005-07-01), Dolitzky et al.
patent: 454436 (1995-09-01), None

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