Processes for the synthesis of 3-(substituted indolyl-2-yl)prope

Details Processes for the synthesis of 3-(substituted indolyl-2-yl)prope Processes for the synthesis of 3-(substituted indolyl-2-yl)prope

1992-11-23

1994-03-01

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548494, C07D20912

Patent

active

052909468

ABSTRACT:
A process for synthesizing compounds of the formula ##STR1## utilizing, as intermediates, oxalyl chloride or bromide and compounds of the formulae R.sub.1 R.sub.2 N--CHO and CH.sub.2 .dbd.CH--O--R.sub.10 are processes for synthesizing compounds of the formula ##STR2## utilizing, as intermediates, compounds of Formula I wherein R.sub.1 is phenyl or substituted phenyl or intermediates in the synthesis of the compounds of formula I which intermediates have the formula ##STR3## wherein R.sub.1 is C.sub.1-3 alkyl, phenyl or phenyl substituted by 1 to 3 substituents each of which is independently C.sub.1-3 alkyl, C.sub.1-3 alkoxy, fluoro, chloro, bromo or nitro (maximum of two nitro groups),

REFERENCES:
patent: 4739073 (1988-04-01), Kathawala
Eilingsfeld et al., Angew. Chem. 72, 836-845 (1960).
Liebscher et al., Synthesis 1979, 241-264.

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