Processes for the production of α-difluoromethyl...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Reexamination Certificate

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C558S441000

Reexamination Certificate

active

07012158

ABSTRACT:
Provided are processes and synthetic intermediates useful for the preparation of α-difluoromethylornithine (DFMO) having the formula

REFERENCES:
patent: 6730809 (2004-05-01), Zhu et al.
Seki et al , Convenient synthesis of alph-difluoromethylornithine, Jun., 1993, Biscience, Biotech, and Biochem. , vol . 57, p. 1024-1025.
P.Bey et al , Catalytic Irreversible Inhibition of mammalian Ornithine Decaaarboxylase by substrate and product analogues, 1978, J. Am. chem. soc. , 100, p. 2551-2553.

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