Processes for the production of anti-inflammatory steroids

Details Processes for the production of anti-inflammatory steroids Processes for the production of anti-inflammatory steroids

1997-10-07

1999-08-17

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

540 70, C07J 7100, A61K 3158

Patent

active

059394099

ABSTRACT:
Disclosed are processes for preparing the 22R and 22S epimers of the compound ##STR1## The processes involve acetalization, transacetalization, hydrolysis (of an ester) or hydrogenation (of a diene) of an appropriate starting material. Also disclosed are pharmaceutical compositions comprising the compounds produced by the processes and methods of treatment of inflammatory and allergic conditions employing the compounds.

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patent: 5614514 (1997-03-01), Axelsson et al.
patent: 5674861 (1997-10-01), Andersson et al.
Thalen et al., Acta Pharm. Suec. (1984), 21(2), 109-24.
Thalen et al., Acta. Pharm. Suec. (1987), 24, 97-114.
Andersson et al. Xenobiotica (1987), 17(1), 35-44.

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