Processes for the preparation of trans 1,3,4,6,7,11b-hexahydro-7

Details Processes for the preparation of trans 1,3,4,6,7,11b-hexahydro-7 Processes for the preparation of trans 1,3,4,6,7,11b-hexahydro-7

1985-07-25

1988-09-20

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544384, 544401, C07B 3710, C07D48704, C07D24104, C07D24108

Patent

active

047727055

ABSTRACT:
The trans isomeric form of 1,3,4,6,7,11b-hexahydro-7-aryl-2H-pyrazino[2,1-a]isoquinolines are prepared using novel 3-phenyl-4-arylacyl-2-piperazinones and 3-phenyl-4-(2-hydroxy-2-arylethyl) piperazines as intermediates. The process involves reacting a nove piperazinone with a reducing agent such as aluminum hydrides, borane or lithium borohydrides, and then reacting the resulting piperazine with a strong acid, such as polyphosphoric or sulfuric acid.

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