Processes for the preparation of tomoxetine

Details Processes for the preparation of tomoxetine Processes for the preparation of tomoxetine

2008-04-08

2008-04-08

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

Reexamination Certificate

active

11170429

ABSTRACT:
Provided are processes for preparing tomoxetine comprising reacting N-methyl-3-hydroxy-3-phenylpropylamine with dimethylsulfoxide (DMSO) and 2-fluorotoluene in the presence of an alkali base to form tomoxetine. Also provided is the conversion of said tomoxetine into atomoxetine or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4018895 (1977-04-01), Molloy et al.
patent: 4777291 (1988-10-01), Misner
patent: 4868344 (1989-09-01), Brown
patent: 5658590 (1997-08-01), Heillgenstein et al.
patent: 6333198 (2001-12-01), Edmeades et al.
patent: 6541668 (2003-04-01), Kjell et al.
patent: 41 23 253 (1993-01-01), None
patent: 0 052 492 (1982-05-01), None
patent: 0 193 405 (1986-09-01), None
patent: 0 721 777 (1995-01-01), None
patent: WO 94/00416 (1994-01-01), None
patent: WO 00/58262 (2000-10-01), None
patent: WO 00/64855 (2000-11-01), None
patent: WO 2006/004923 (2006-01-01), None
patent: WO 2006/004976 (2006-01-01), None
patent: WO 2006/004977 (2006-01-01), None
patent: WO 2006/004979 (2006-01-01), None
patent: WO 2006/020348 (2006-02-01), None
Srebnik, M. et al. “Chiral Synthesis via Organoboranes. 18. Selective Reductions. 43. Dissopinocampheylchloroborane as an Excellent . . . ” J. Org. Chem. (1988), vol. 53, p. 2916-2920.
Anon (R)-(-)-N-Methyl-3-(2-Methylphenoxy)Phenyl-3-Phenylpropylamine (S)-(+)-Mandelate Chemical Abstracts Service XP-002367858 Dec. 29, 2004.
Koenig, T.M. et al. “A Convenient Method for Preparing Enantiomerically Pure Norfluoxetine, Fluoxetine and Tomoxetine” Tetrahedron Letters, vol. 35, No. 9, pp. 1339-1342 (1994).
Strobel, H.A.; Heineman, W.R., Chemical Instrumentation: A Systematic Approach, 3rd dd. (Wiley & Sons: New York 1989)—pp. 391-393, 879-894, 922-925, 953.
Snyder, L.R.; Kirkland, J.J., Introduction to Modem Liquid Chromatography, 2nd ed. (John Wiley & Sons: New York 1979)—p. 549-552, 571-572.
Sellers, J.A. et al. “Determination of the Enantiomer and Positional Isomer Impurities in Atomoxetine Hydrochloride with Liquid Chromatography Using Polysaccharide Chiral Stationary Phases.”J. of Pharmaceutical and Biomedical Analysis, vol. 41, pp. 1088-1094 (2006).

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