Processes for the preparation of substituted sulfoxides

Details Processes for the preparation of substituted sulfoxides Processes for the preparation of substituted sulfoxides

2011-03-29

2011-03-29

Morris, Patricia L (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07915422

ABSTRACT:
The present invention relates to a process for enantioselective synthesis of substituted pyridinylmethyl sulfinyl-benzimidazole of compound of Formula (I). The process includes enantioselective catalytic oxidation of a substituted pyridinylmethyl prochiral sulfide derivative of compound of Formula (II) with an oxidizing agent in the presence of a chiral transition metal complex and a base in the absence of an organic solvent.

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Zhao et al., “Asymmetric Oxidation of Sulfides Mediated by Chiral Titanium Complexes: Mechanistic and Synthetic Aspects”,Tetrahedron, 43(21):5135-5144 (1987).
Pitchen et al. “An Efficient Asymmetric Oxidaton of Sulfides to Sulfoxides”,Journal of the American Chemical Society, 106(26):8188-8193 (1984).

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