Processes for the preparation of S-(-)-amlodipine

Details Processes for the preparation of S-(-)-amlodipine Processes for the preparation of S-(-)-amlodipine

2007-04-10

2007-04-10

Morris, Patricia L. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

10527091

ABSTRACT:
Provided is a process for the preparation of S-(−)-amlodipine from (R,S)-amlodipine in industrial-scale using L-(+)-tartaric acid, which is much cheaper than D-(−)-tartaric acid.

REFERENCES:
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Arrowsmith, J.E., et al., “Long-Acting Dihydropyridine Calcium Antagonists 1. 2-Alkoxymethyl Derivatives Incorporating Basic Substituents,” J. Med. Chem., 1986, pp. 1696-1702, vol. 29.
Goldmann, S. et al., “Determination of the Absolute Configuration of the Active Amlodipine Enantiomer as(-)-S: a Correction,” J. Med. Chem., 1992, pp. 3341-3344, vol. 35.

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