Processes for the preparation of rocuronium bromide and...

Details Processes for the preparation of rocuronium bromide and... Processes for the preparation of rocuronium bromide and...

2005-01-13

2009-08-25

Badio, Barbara P (Department: 1612)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07579461

ABSTRACT:
A novel process for preparing (2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl) androstane, a known intermediate in the synthesis of the skeletal muscle relaxant rocuronium bromide, is disclosed.

REFERENCES:
patent: 5817803 (1998-10-01), Magni et al.
patent: 0287150 (1988-10-01), None
patent: WO 2005/068487 (2005-07-01), None
Slavikova et al., “Dihydrotestosterone with an ammonium centre in the position 16beta.” Collect. Czech. Chem. Commun., vol. 62, pp. 656-664, 1997.
Tuba et al. “Synthesis and Structure—Activity Relationship of Neuromuscular Blocking Agents”, Current Medicinal Chemistry, 9(16): 1507-1536, 2002.

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