Processes for the preparation of piperazinyl and diazapanyl...

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07728129

ABSTRACT:
The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides of formula (I), as defined in the specification, useful for the treatment of disorders and conditions mediated by the histamine receptor.

REFERENCES:
patent: 6548670 (2003-04-01), Burdeniue
patent: 7414047 (2008-08-01), Apodaca et al.
patent: 2003/0163002 (2003-08-01), Kramer
patent: 2004/0110746 (2004-06-01), Apodaca et al.
patent: WO 01/77064 (2001-10-01), None
patent: WO 2004/037801 (2004-05-01), None
Dörwald, F. Zaragoza. Side Reactions in Organic Synthesis: A Guide to Successful Synthesis Design, Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA, 2005, Preface.
Souillac, et al., Characterization of Delivery Systems, Differential Scanning Calorimetry, pp. 217-218 (in Encyclopedia of Controlled Drug Delivery, 1999, John Wiley & Sons, pp. 212-227).
Vippagunta et al. Advanced Drug Delivery Reviews, 48 (2001), pp. 3-26.
PCT/US2006/041859 International Search Report, Apr. 25, 2007.
Ates-Alagoz, Z. et al. Synthesis of Some Novel Tetrahydronaphthalene Benzimidazole Derivatives. Het. Commun. 2001, 7(5), 455-460.
Beke, D. et al. Eine neue Synthese des N-Isopropyl-nor-adrenalins. Pharmazeutische Zentralhalle fuer Deutschland 1953, 92, 237-241. (English language abstract provided.).
Kjell, D.P. et al. A Novel, Nonaqueous Method for Regenration of Aldehydes from Bisulfite Adducts. J. Org. Chem. 1999, 64, 5722-5724.
Johnson, T.J. et al. The Chemistry of Terpenes—VIII. Characterisation of the Bisulphite Adducts of α,β-Unsaturated Aldehydes by NMR Spectroscopy. Tetrahedron 1978, 34, 547-551.
Mitra, A.K. et al. Regeneration of Aldehydes from Bisulfite Addition Products in the Solid State using Montmorillonite KSF Clay under Microwave Irradiation. J. Chem. Research (S) 1999, 9, 560-561.
Paglietti, G. et al. Preparazione e Attivita' Farmacologica di 2-(4′R′)Feni1-5R-Benzimidazoli e 2-(4′Piridinil)-5R-Benzimidazoli. II Farmaco 1988, 43(3), 215-226. (English language abstract provided.).
Ragan, J.A. et al. Safe Execution of a Large-Scale Ozonolysis: Preparation of the Bisulfite Adduct of 2-Hydroxyindan-2-carboxaldehyde and Its Utility in a Reductive Amination. Org. Process Res. Dev. 2003, 7, 155-160.
Ridley, H.F. et al. A New Synthesis of Benzimidazoles and Aza-analogs. J. Het. Chem. 1965, 2(4), 453-456.
Servi, S. et al. A Novel and Efficient Synthesis of 3-Aryl and 3-Heteroaryl Substituted-1H-Indazoles and Their Mannich Derivatives. Synth. Commun. 2002, 33(22), 3399-3405.
Shaikh, I.A. et al. Streptonigrin. 1. Structure-Activity Relationships among Simple Bicyclic Analogues. Rate Dependence of DNA Degradation on Quinone Reduction Potential. J. Med. Chem. 1986, 29, 1329-1340.
Temple, Jr., C. et al. Synthesis of Potential Anticancer Agents: Imidazo[4,5-c]pyridines and Imidazo[4,5-b]pyridines. J. Med. Chem. 1987, 30, 1746-1751.
von der Saal, W. et al. Nonsteroidal Cardiotonics. 2. The Inotropic Activity of Linear, Tricyclic 5-6-5 Fused Heterocycles. J . Med. Chem. 1989, 32, 1481-1491.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Processes for the preparation of piperazinyl and diazapanyl... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Processes for the preparation of piperazinyl and diazapanyl..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Processes for the preparation of piperazinyl and diazapanyl... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4230327

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.