Processes for the preparation of peripheral opioid...

Details Processes for the preparation of peripheral opioid... Processes for the preparation of peripheral opioid...

2006-08-15

2006-08-15

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S238000

Reexamination Certificate

active

07091354

ABSTRACT:
Novel processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto. The compounds prepared by the present processes may be useful, for example, as antagonists to the mu, kappa and delta opioid receptors, and thereby may be useful in the treatment of gastrointestinal motility disorders, and in preventing peripheral opiate induced side effects. The present processes may offer improved yields, purity, ease of preparation and/or isolation of intermediates and final product, and more industrially useful reaction conditions and workability.

REFERENCES:
patent: 5159081 (1992-10-01), Cantrell et al.
patent: 5250542 (1993-10-01), Cantrell et al.
patent: 5270328 (1993-12-01), Cantrell et al.
patent: 5434171 (1995-07-01), Frank et al.
patent: 6451806 (2002-09-01), Farrar
patent: 6469030 (2002-10-01), Farrar et al.
Barton, D.H.R., et al., “Improved methods for the radical deoxygenation of secondary alcohols,”Tetrahedron Lett., 1989, 30(20), 2619-2622.
Barton, D.H.R., et al., “On the mechanism of deoxygenation of secondary alcohols by tin hydride reduction of methyl xanthates and other thiocarbonyl derivatives,”Tetrahedron Lett., 1990, 31(28), 3991-3994.
Boussaguet, P., et al., “Catalytic and supported barton—McCombie deoxygenation of secondary alcohols: a clean reaction,”Tetrahedron Lett., 2000, 41, 3377-3380.
Dorland's Illustrated Medical Dictionary, 27thEd.,W.B. Saunders Company, Philadelphia, PA, 1988, 816.
Dorland's Illustrated Medical Dictionary, 27thEd.,W.B. Saunders Company, Philadelphia, PA, 1988, 1995, 375.
Gevorgyan, V., et al., “A novel B(C6F5)3-catalyzed reduction of alcohols and cleavage of aryl and alkyl ethers with hydrosilanes,”J. Org. Chem., 2000, 65, 6179-6186.
Lidstrom, P., et al., “Microwave assisted organic synthesis—a review,”Tetrahedron, 2001, 57(45), 9225-9283.
Livingston, E.H., et al., “Postoperative ileus,”Digestive Diseases and Sciences, Jan. 1990, 35(1), 121-132.
Perlmutter, P., et al., “Diastereoselection in the nucleophilic conjugate addition of amines to 2-hydroxyalkylpropenoates,”J. Org. Chem., 1988, 29(8), 949-952.
Perlmutter, P., et al., “A simple route to α-substituted-β-amino ester precursors of carbapenem antibiotics,”J. Org. Chem., 1995, 60, 6515-6522.
Resnick, J., et al., “Delayed gastric emptying and postoperative ileus after nongastric abdominal surgery: Part 1,”J. Am. J. Gastroenterology, 1997, 92(5), 751-762.
Resnick, J., et al., “Delayed gastric emptying and postoperative ileus after nongastric abdominal surgery: Part II,”J. Am. J. Gastroenterology, 1997, 92(6), 934-940.
Sakai, T., et al., “Me3SiC1-NaI-CH3CN as an efficient and practical reducing agent for benzylic alcohols,”Tetrahedron Lett., 1987, 28(33), 3817-3818.
Werner, J.A., et al., “Synthesis oftrans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists: application of theCis-thermal elimination of carbonates to alkaloid synthesis,”J. Org. Chem., 1996, 61, 587-597.

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