Processes for the preparation of macrocyclic ketones

Details Processes for the preparation of macrocyclic ketones Processes for the preparation of macrocyclic ketones

2005-03-01

2005-03-01

Killos, Paul J. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C568S346000, C568S354000

Reexamination Certificate

active

06861551

ABSTRACT:
Disclosed are a process of subjecting a diester of a long-chain dicarboxylic acid having 18 to 21 carbon atoms to intramolecular condensation in the presence of titanium tetrachloride or zirconium tetrachloride and a trialkylamine to form an α-alkoxycarbonylated macrocyclic ketone, and a process for producing a macrocyclic ketone by hydrolyzing an α-alkoxycarbonylated macrocyclic ketone obtained by the process and then subjecting the hydrolyzate to decarboxylation. The invention provides a process for producing a macrocyclic ketone efficiently, which permits high concentration synthesis.

REFERENCES:
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