Processes for the preparation of liposome drug delivery systems

Details Processes for the preparation of liposome drug delivery systems Processes for the preparation of liposome drug delivery systems

1984-09-07

1985-11-05

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

2101982, 264 41, 424 11, 436829, B01J 1302, A61K 950

Patent

active

045512884

ABSTRACT:
Process and apparatus for the production of medicament containing liposomes, comprising an aliphatic lipid-sterol-water lamellae, wherein a clear, mixed micellar medicament-detergent-aliphatic lipid-sterol sample is applied to a gel filtration column. The column effluent is continuously monitored to detect the liposome fraction eluted, which is collected. The free medicament, detergent, lipid and/or sterol may be recirculated back to the column.

REFERENCES:
patent: 3155590 (1964-11-01), Miller et al.
patent: 3657144 (1972-04-01), Yoshida
patent: 4089801 (1978-05-01), Schneider
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4308166 (1981-12-01), Marchetti et al.
patent: 4310506 (1982-01-01), Baldeschwieler et al.
patent: 4356167 (1982-10-01), Kelly
Rhoden et al.: "Formation of Unilamellar Lipid Vesicles of Controllable Dimensions by Detergent Dialysis", Biochemistry, vol. 18, No. 19 (1979) pp. 4173-4176.

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