Processes for the preparation of cephalosporin derivatives

Details Processes for the preparation of cephalosporin derivatives Processes for the preparation of cephalosporin derivatives

2004-10-30

2009-11-24

Berch, Mark L (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07622577

ABSTRACT:
Provided is a process for preparing a compound of formula 1 or its salt, which comprises reacting a compound represented by the following formula 4 with acetaldehyde in a mixed solvent comprising water, isopropanol, and methylenechloride in a volume ratio of 1:3-6:11-14 in the presence of a first base to stereospecifically prepare a compound represented by the following formula 3′; andreacting the compound of the formula 3′ with an anhydrous compound represented by the following formula 2 in the presence of a second base:wherein R1is a hydrogen or an amino protecting group, R2is a hydrogen or a carboxyl protecting group, and R3is a hydrogen or an amino protecting group consisting of phenylacetyl group,wherein when R3is a phenylacetyl group, R2is not a hydrogen in formula 3′; andwherein, when at least one of R2and R3is a protecting group, all such protecting groups are removed from formula 3′, thereby producing a compound represented by formula 6 prior to reacting it with the compound of formula 2.

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Indian Office Action issued in IN 2320/DELNP/2006 dated Mar. 17, 2009, 6 pages.

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