Processes for the preparation of atomoxetine hydrochloride

Details Processes for the preparation of atomoxetine hydrochloride Processes for the preparation of atomoxetine hydrochloride

2005-09-07

2008-10-21

Davis, Brian J (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S348000

Reexamination Certificate

active

07439399

ABSTRACT:
The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HCl by adding HCl to a mixture of (R)-(−)-tomoxetine (S)-(+)-mandelate with an organic solvent, with or without a base and water. In preferred embodiments, the atomoxetine hydrochloride produced is Form A.

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