Processes for the preparation of 2-aminomethylpyridines and...

Details Processes for the preparation of 2-aminomethylpyridines and... Processes for the preparation of 2-aminomethylpyridines and...

2008-01-22

2008-01-22

Morris, Patricia L. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S286000

Reexamination Certificate

active

07321043

ABSTRACT:
Disclosed herein is a process for the preparation of a compound of the formula (II):or a salt thereof, wherein X is halogen; each Y, which may be the same or different, is halogen, haloalkyl, alkoxycarbonyl or alkylsulphonyl, and n is 0 to 3;which process comprises treating a compound of the formula (III):with a cyanide source and a catalyst selected from the group consisting of a tetraalkyl ammonium salt and a tetraalkyl phosphonium salt in an aqueous solvent or without solvent, wherein:X is halogen; each Y, which may be the same or different, is halogen, haloalkyl, alkoxycarbonyl or alkylsulphonyl: and n is 0 to 3; and wherein the cyanide source is hydrogen cyanide, an alkali metal cyanide, an alkaline earth metal cyanide or an optionally substituted ammonium cyanide.

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