Processes for the in vitro culture, attenuation of the virulence

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of...

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435 4, 435 71, 435 722, 435 221, 435 34, 435 41, 435245, 4352581, 4352574, 4352557, 435 7013, 4352401, 424 937, 4242701, C12N 100, C12N 110, A01N 6300, A61K 39018

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ABSTRACT:
The present invention provides a process for the in vitro culture of parasites of the genus Babesia, processes for the in vitro attenuation of the virulence of these parasites, processes for the in vitro cloning of these parasites, attenuated parasites, clonal lines of the genus Babesia, nucleotide probes derived from the clonal lines, the use of these probes for the identification of Babesia parasites and to vaccinces against babesioses.

REFERENCES:
patent: 4590072 (1986-05-01), Buening et al.
patent: 4777036 (1988-10-01), Laurent
International Parasitology, vol. 23, No. 6, Sep. 1993, pp. 771-776.
Veterinary Parasitology, vol. 31, No. 3, Jun. 1989, pp. 243-251.
Chemical Abstracts, WO 91/11776, 1991.
Chemical Abstracts, EP 417,524, 1995.
Davis et al. (1984) J. Clin. Invest. vol. 74, 269-278.

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