Processes for purification of 2,4-di(1-pyrrolidinyl)-6-chloropyr

Details Processes for purification of 2,4-di(1-pyrrolidinyl)-6-chloropyr Processes for purification of 2,4-di(1-pyrrolidinyl)-6-chloropyr

1992-08-19

1993-07-06

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544295, 544296, 544122, C07D40314

Patent

active

052255557

ABSTRACT:
The present invention involves two processes for the purification of a mixture of 2,4-di(1-pyrrolidinyl)-6-chloropyrimidine (III) ##STR1## and 4,6-di(1-pyrrolidinyl)-2-chloropyrimidine (IV) ##STR2## to where <1.0% of 4,6-di(1-pyrrolidinyl)-2-chloropyrimidine (IV) is present. In addition also disclosed is a process which not only purifies 2,4-di(1-pyrrolidinyl)-6-chloropyrimidine (III) but produces the commercially important 2,4-di(1-pyrrolidinyl)-6-(1-piperazinyl)pyrimidine (IX) directly.

REFERENCES:
patent: 4025515 (1977-05-01), Schneider
patent: 4082535 (1978-04-01), Hoegerle
patent: 4996318 (1991-02-01), Gall

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