Processes for production of optically active 4-halo-3-hydroxybut

Details Processes for production of optically active 4-halo-3-hydroxybut Processes for production of optically active 4-halo-3-hydroxybut

1994-01-12

1996-09-24

Naff, David M.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435135, 435822, 435911, C12P 740

Patent

active

055590306

ABSTRACT:
A microorganism that is capable of acting on a 4-halo-acetoacetic acid ester shown by the general formula: ##STR1## wherein X represents a halogen atom and R represents an optionally substituted alkyl group, alkenyl group, cycloalkyl group or aryl group, to produce an optically active 4-halo-3-hydroxybutyric acid ester or a preparation thereof is permitted to act on said 4-halo-acetoacetic acid ester and the product optically active 4-halo-3-hydroxybutyric acid ester is harvested. Thus, the desired optically active 4-halo-3-hydroxybutyric acid ester of high optical purity can be produced with commercial efficiency.

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