Processes for producing .alpha.-cyanohydrin esters and .alpha.-h

Details Processes for producing .alpha.-cyanohydrin esters and .alpha.-h Processes for producing .alpha.-cyanohydrin esters and .alpha.-h

1998-12-17

2000-08-29

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

558351, C07C26300, C07C24900

Patent

active

061111287

ABSTRACT:
In the presence of a metal catalyst such as a samarium compound, an enol ester compound shown by the formula (1) is reacted with a carbonyl compound shown by the formula (3) and a cyanogenation agent to produce an .alpha.-cyanohydrin ester shown by the formula (4): ##STR1## wherein R.sup.1, R.sup.7, and R.sup.8 are the same or different from each other, each representing a non-reactive atom or a non-reactive organic group; R.sup.2, R.sup.3, and R.sup.4 are the same or different from each other, each representing a hydrogen atom or an alkyl group having 1 to 5 carbon atoms.
By hydrolyzing the obtained compound, the corresponding .alpha.-hydroxy acid or a salt thereof can be obtained. According to the above processes, an .alpha.-cyanohydrin ester and an .alpha.-hydroxy acid can be obtained in high yields.

REFERENCES:
patent: 4113763 (1978-09-01), Norton
patent: 4299776 (1981-11-01), Hatch, III
J. March, Advanced Organic Chemistry, 4th Edition, XP002097784, pp.397-398 (1992).

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