Processes for producing 7-isoindoline-quinolonecarboxylic...

Details Processes for producing 7-isoindoline-quinolonecarboxylic... Processes for producing 7-isoindoline-quinolonecarboxylic...

2008-05-13

2008-05-13

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S405000, C548S466000

Reexamination Certificate

active

11691740

ABSTRACT:
Process for producing a 7-bromoquinolone-carboxylic acid derivative of the following formula or its saltby reacting a 2,4-dibromo-3-hydroxybenzoic acid ester compound of the formulain-line-formulae description="In-line Formulae" end="lead"?R7a-xin-line-formulae description="In-line Formulae" end="tail"?to obtain a 3-alkoxy-2,4-dibromobenzoic acid ester, subjecting the 3-alkoxy-2,4-dibromobenzoic acid ester to elimination reaction of the carboxyl-protecting group to obtain a 3-alkoxy-2,4-dibromobenzoic acid, subjecting the 3-alkoxy-2,4-dibromobenzoic acid to ketoesterification reaction to obtain a 3-alkoxy-2,4-dibromobenyolacetic acid ester, reacting the 3-alkoxy-2,4-dibromobenzoylacetic acid ester with an orthoester or an acetal, then reacting the reaction product with a compound of the formula R2—NH or its salt to obtain a 2-(3-alkoxy-2,4-dibromobenzoyl)-3-substituted aminoacrylic acid ester and subjecting the 2-(3-alkoxy-2,4-dibromobenzoyl)-3-substituted aminoacrylic acid ester to ring-closing reaction, and products thereof.

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