Processes for producing 5-fluorobenzoic acids and their intermed

Details Processes for producing 5-fluorobenzoic acids and their intermed Processes for producing 5-fluorobenzoic acids and their intermed

1990-11-15

1993-08-31

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

558318, 570127, C07C 6304

Patent

active

052411117

ABSTRACT:
A process for producing a 5-fluorobenzoic acid of the formula (V), which comprises trichloromethylating a fluorobenzene of the formula (I) to obtain a 5-fluorobenzotrichloride of the formula (II), then reacting it with aqueous ammonia to obtain a 5-fluorobenzonitrile of the formula (III), reacting it with a fluorinating agent to obtain a 5-fluorobenzonitrile of the formula (IV) and hydrolyzing it: ##STR1## wherein each of X.sub.1, X.sub.3, Y.sub.1 and Y.sub.3 is a halogen atom, and each of X.sub.2 and Y.sub.2 is hydrogen or a halogen atom.

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Chemical Abstracts, 77918q, vol. 113, No. 9, Aug. 27, 1990, & CN-A-1 031 074, Feb. 15, 1989, Y. Shi, et al., "Preparation of 2,4-Dichloro-5-Fluorobenzoic Acid".
Patent Abstracts of Japan, vol. 13, No. 205, (C-595) [3553], May 15, 1989, & JP-A-1 025 737, Jan. 27, 1989, S. Niizeki, et al., "Decarboxylation of Halogen-Substituted Benzenecarboxylic Acid".
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