Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
2007-03-05
2009-10-20
Kifle, Bruck (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
active
07605257
ABSTRACT:
Processes are described for preparing 42-pegylated rapamycins including reacting a rapamycin with an acylating agent in the presence of a lipase to form an acylated rapamycin and reacting the acylated rapamycin with a methoxy poly(ethylene glycol) derivative in the presence of a base. Also described are processes for preparing 32-pegylated tacrolimus and/or ascomycin using these steps.
REFERENCES:
patent: 5362718 (1994-11-01), Skotnicki et al.
patent: 5780462 (1998-07-01), Lee et al.
patent: 5955457 (1999-09-01), Lee et al.
patent: 6277983 (2001-08-01), Shaw et al.
patent: 6331547 (2001-12-01), Zhu et al.
patent: 6432973 (2002-08-01), Zhu et al.
patent: 6440990 (2002-08-01), Cottens et al.
patent: 2002/0055518 (2002-05-01), Zhu
patent: 2005/0234087 (2005-10-01), Gu et al.
patent: 2005/0234234 (2005-10-01), Gu et al.
patent: WO-99/03860 (1999-01-01), None
patent: WO 2005/105812 (2005-11-01), None
Lopez-Pelegrin, Soluble Polymer-Supported Chemoenzymatic Synthesis of the C21-C27 Fragment of the Bryostatins, J. Org. Chem., vol. 65, No. 25, pp. 8527-8531, (Dec. 2000).
Uyama Hiroshi et al, Immobilized Lipase Showing High Catalytic Activity Toward Enzymic Ring-Opening Polymerization of Macrolides, Chemisry Letters, Chemical Society of Japan, vol. 2, pp. 107-108, (1996).
Rosen et al., “Natural Products as Probes of Cellular Function: Studies of Immunophilins”, Angew. Chem. Int. Ed. Engl., 31:384-400 (Apr. 1992).
Yatscoff et al., “Rapamycin: Distribution, Pharmacokinetics, and Therapeutic Range Investigations”, Ther. Drug. Monit., 17:666-671 (Dec. 1995).
Greenwald et al., “Effective Drug Delivery by PEGylated Drug Conjugates”, Advanced Drug Delivery Rev., 55:217-250 (Feb. 2003).
Pasut et al., “Protein, Peptide and Non-Peptide Drug PEGylation for Therapeutic Application”, Expert Opin. Ther. Patents, 14:859-894 (Jun. 1, 2004).
First Official Action in counterpart Pakistan application, pp. 3, (2008).
Fawzi Mahdi
Gu Jianxin
Ruppen Mark
Zhu Tianmin
Howson & Howson LLP
Kifle Bruck
Rubin, Esq. David A.
Wyeth
LandOfFree
Processes for preparing water-soluble polyethylene glycol... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Processes for preparing water-soluble polyethylene glycol..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Processes for preparing water-soluble polyethylene glycol... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4077600