Processes for preparing prostaglandins

Details Processes for preparing prostaglandins Processes for preparing prostaglandins

1989-12-13

1992-05-12

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560121, C07C17700

Patent

active

051130149

ABSTRACT:
A process for the preparation of a prostaglandin of the formula ##STR1## wherein n is 1, 2, 3 or 4, R.sub.1 and R.sub.2, independently of each other, are alkyl, OH, alkoxy, ketone, halogen, hydrogen, nitro, amino or ether,

REFERENCES:
Journal of the American Chemical Society Nov. 29, 1972; Efficient Generation of the 15S Configuration in Prostaglandin Synthesis. Attractive Interactions in Stereochemical Control of Carbonyl Reduction. pp. 8616-8618.
Journal of the American Chemical Society 1988; pp. 4718-4726; The Three-Component Coupling Synthesis of Prostaglandins. M. Suzuki, et al vol. 110.
Journal of the American Chemical Society, 1988, vol. 110; pp. 4726-4735 Triply Convergent Synthesis of (-)-Prostaglandin E.sub.2 Methyl Ester; Carl R. Johnson et al.
Communications to the Editor; pp. 4745-4746; A General Approach to Prostaglandins via Methylenecyclopentanones. Total Synthesis of (.+-.)-Prostaglandin F.sub.2.alpha. (1975).
Communications to the Editor pp. 5843-5844; (1979).
Tetrahedron Letters, vol. 23, No. 39 pp. 4057-4060, 1982; A Facile Synthesis of (-)-Prostaglandin E.sub.1 Via a Three-Component Coupling Process M. Suzuki et al.
Tetrahedron Letters, vol. 27, No. 20, pp. 2199-2202, 1986; A New Synthetic Route to Prostaglandins; E. J. Corey et al.
Tetrahedron Letters, vol. 28, No. 46, pp. 5655-5658, 1987; Synthesis of Novel Prostaglandin F.sub.2 Isomers and structure of an enzymatically formed 13-Hydroxyprostaglandin Endoperoxide; Ute Hofmann et al.
Angew. Chemical Int. Ed. Engl. 22 1983; pp. 803-815; From Studies of Biochemical Mechanism to Novel Biological Mediators: Prostaglandin Endoperoxides Thromboxanes, and Leukotrienes (Nobel Lecture).
Danishefsky et al., I JACS 111, 3456 (1989).
Danishefsky et al., II JOC 54 6016 (1989).
Danishefsky et al. JACS 111 2599 (1989).

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