Processes for preparing optically active alcohols and optically

Details Processes for preparing optically active alcohols and optically Processes for preparing optically active alcohols and optically

1996-04-05

1998-09-01

Burn, Brian M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564489, 564413, C07C20940

Patent

active

058012800

ABSTRACT:
A process for preparing an optically active alcohol by reacting a prochiral ketone corresponding to the optically active alcohol and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active .beta.-aminoalcohol and a boron hydride; or obtained from the optically active .beta.-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine and (2) a metal borohydride; and a process for preparing an optically active amine by reacting an oxime derivative and an acid with a mixture of (1) a boron-containing compound selected from the group consisting of i) a borane compound which is obtained from an optically active .beta.-aminoalcohol and a boron hydride, or obtained from said optically active .beta.-aminoalcohol, a metal borohydride and an acid and ii) an optically active oxazaborolidine, and (2) a metal borohydride.

REFERENCES:
patent: 5200561 (1993-04-01), Konya et al.
patent: 5442118 (1995-08-01), Gao et al.
patent: 5574186 (1996-11-01), Boudreau et al.
S. Itsuno et al., J. Chem. Soc. Perkin Trans 1, 1985, pp. 2039-2044.
Tetrahedron Letters, vol. 29, No. 2, 1988, Oxford GB, pp. 223-224, Y. Sakito et al.: "Asymmetric reduction of oxime ethers. Distinction of anti and syn isomers leading to enantiomeric amines".
Database WPI Section Ch, Week 9528, Derwent Publications Ltd., London, GB; Class B03, AN 95-209417 (1995).

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