Processes for preparing intermediates of pemetrexed

Details Processes for preparing intermediates of pemetrexed Processes for preparing intermediates of pemetrexed

2011-08-09

2011-08-09

Moore, Susanna (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S280000

Reexamination Certificate

active

07994180

ABSTRACT:
The invention provides intermediates of pemetrexed of formula VI and processes for the preparation thereof.

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U.S. Pharmacopeia, 387-389 (30th ed. 2007).
Kjell, Douglas P., et al., “Determination of the Source of theN-Methyl Impurity in the Synthesis of Pemetrexed Disodium Heptahydrate,”Organic Process Research and Development, 9(6): 738-742 (2005).
International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Harmoniszed Tripartite Guideline: Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients Q7 (Current Step 4 version, Nov. 10, 2000) (available at http://www.ich.org/LOB/media/MEDIA433.pdf, last visited Dec. 21, 2007).

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